One of the first in vivo demonstrations that cohesin loss in non-dividing cells can impact physiology, specifically impairing the immune function of dendritic cells in mice. Now out in Science Immunology!

Check out the issue cover: it features CTCF-cohesin chromatin loops artistically rendered as dendritic cells. While real chromatin loops are much more “crumpled” and CTCFs-cohesin-DNA interaction interfaces more complex, the message is clear: we’ve learned so much about chromatin organization, and it’s time to apply that knowledge to complex biological systems like the immune response.

N. A. Adams*, A. Galitsyna*, … L. A. Mirny, B. Reizis “Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells” Science Immunology, 11 eadx4622 (2026). DOI: 10.1126/sciimmunol.adx4622

https://doi.org/10.1126/sciimmunol.adx4622