The second week of December 2024, I have attended 2024 4DN Annual Meeting in San Diego. I presented my work on the chromatin of the dendritic cells to the chromatin biology community. My poster:
A very curious part of my PhD work on Dictyostelium discoideum chromatin has been published in Nucleic Acid Research this week. My part was designing a 1D extrusion and polymer model to explain why the “bright dots” are happening at the convergent gene positions (CGPs).
I’m pleased to share the results of a project I started during my graduate studies, now beautifully completed by my colleagues.
The study applies a sophisticated method to construct joint embeddings of DNA sequences and Hi-C chromatin organization maps within a shared space. This framework allows for the exploration of chromatin structures with distinct functional characteristics, such as insulation domains, loops, and fountains. Intriguingly, it also enables us to identify DNA sequences associated with specific structural features and even modify chromatin maps by ‘adding’ these elements.
One particularly striking result is the construction of a ‘tree of life’ for chromatin spatial organization. While it bears some similarity to traditional phylogenetic trees based on DNA sequences, there are notable differences that reflect significant evolutionary shifts in mechanisms of chromatin folding.
https://www.biorxiv.org/content/10.1101/2024.11.14.623548v2
Does chromatin organization shape immune responses? Our recent study with Nick Adams led by Reizis Lab and Leonid Mirny explores